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Lyle McKinnon |
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Country: |
Canada |
| Degree: |
BSc in Biology-U. of Winnipeg
PhD in Medical Microbiology-U. of Manitoba
University of Nairobi/ Toronto – Postdoctoral fellow |
Supervisor:
Project Title: |
Drs. Joshua Kimani, Rupert Kaul
Effect of antiretroviral therapy on mucosal immunology in female sex worker cohorts |
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Description
of the Project: The aim of this study is to determine how antiretroviral therapy affects the mucosal immunology of the female genital tract in high-risk, core transmitter groups in Nairobi, Kenya. This is a longitudinal study that assesses changes in cell populations in the cervix, cytokine milieu, and the effects of genital tract co-infections on shedding of HIV. In addition we will determine the impact of ART on sexual risk taking behaviour and drug resistance patterns. This study has important public health implications for the ability of ART to decrease the odds of HIV transmission from an important core transmitter group. |
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James Sainsbury |
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Country: |
Canada |
| Degree: |
BSc (Victoria University of Wellington)
BSc(Hons) (Victoria University of Wellington)
PhD (Victoria University of Wellington)
University of Manitoba, Postdoctoral Fellow
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Supervisor:
Project Title: |
Dr Frank Plummer
Characterisation of a novel candidate gene for the HIV-1 Resistance Phenotype in the Pumwani Sex Worker Cohort. |
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Description
of the Project: A genomewide association study identified a novel candidate gene for the HIV-1 resistance phenotype in the Pumwani Sex Worker Cohort. James’ project involves the broad characterization of this gene at the level of genome, the transcriptome and the proteome with the goal of identifying mechanisms of HIV-1 protection. |
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